Just sayin...


Appl Physiol Nutr Metab. 2012 Jan 17. [Epub ahead of print]
Acute l-arginine supplementation increases muscle blood volume but not strength performance.
Alvares TS, Conte CA, Paschoalin VM, Silva JT, Meirelles CD, Bhambhani YN, Gomes PS.
Source
a Laboratory Crossbridges, Physical Education Postgraduate Program, Gama Filho University, Rio de Janeiro, Brazil.
Abstract
l-Arginine (L-arg) is an amino acid precursor to nitric oxide (NO). Dietary supplements containing L-arg have been marketed with the purpose of increasing vasodilation, thereby elevating blood flow to the exercising muscle and enhancing the metabolic response to exercise. Our goal was to identify the acute effect of L-arg supplementation on biceps strength performance, indicators of NO production (nitrite and nitrate - NOx), and muscle blood volume (Mbv) and oxygenation (Mox) during recovery from 3 sets of resistance exercise. Fifteen males participated in a randomized, double-blind, placebo-controlled study. After withdrawing resting blood samples, the subjects were supplemented with 6 g of L-arg (ARG) or placebo (PLA). Monitoring of Mbv and Mox with near-infrared spectroscopy began 30 min after supplementation and lasted for 60 min. The exercise protocol (3 sets of 10 maximal voluntary contractions of isokinetic concentric elbow extension at 60°·s(-1), 2-min rest between sets) was initiated 80 min after supplementation. Blood samples were drawn at 30, 60, 90, and 120 min after supplementation. Repeated measures ANOVA showed that Mbv significantly (p ≤ 0.05) increased in ARG compared with the PLA during the recovery period of each set of resistance exercise. NOx, Mox, peak torque, total work, and set total work were not significantly different between groups. We found that acute L-arg supplementation increases Mbv during recovery from sets of resistance exercise with no increase in strength performance. It is still premature to recommend nutritional supplements containing L-arg as an ergogenic aid to increase muscle strength during resistance training in healthy subjects.
PMID: 22251130 [PubMed - as supplied by publisher]

Lol, of course it does, that's why MRi NO2 was such a massive fucking hit, and every pre thereafter, til very recently, included arginine. And it's also why I've said for years it DOES increase pumps, but DOESN'T increase performance.

I saw thread title, thought of posting inb4 poison, got too lazy.

5mins later, posion!

I'm a little lost but why does poison love arginine? I feel like I missed some inside joke.

Originally Posted by Right Hook

I'm a little lost but why does poison love arginine? I feel like I missed some inside joke.

Lol, I don't. I just get irritated when noobs post 'arginine doesn't do anything, use agmatine' or whatever. It's a joke. Arginine increases pumps, but does fuckall else, and arginine has far more clinical evidence than agmatine does in trained athletes.

Personally, I like citrulline, because it actually increases performance, unlike agmatine and arginine.

Originally Posted by MEATHEAD

only good for reducing nitrate tolerance.
Thread is invalid.
do I need to summon illa and no hype to this thread?

Sure. Let them argue with the fine folks at Gama Filho University, Rio de Janeiro, Brazil.

Originally Posted by poison

Lol, I don't. I just get irritated when noobs post 'arginine doesn't do anything, use agmatine' or whatever. It's a joke. Arginine increases pumps, but does fuckall else, and arginine has far more clinical evidence than agmatine does in trained athletes.

Personally, I like citrulline, because it actually increases performance, unlike agmatine and arginine.

I agree with everything you have said.

Originally Posted by MEATHEAD

Only bc all ur pre's have.arginine in them

Because it decreases nitrate tolerance.

I've been saying it for YEARS, long before being a rep. Ask Vaughn. lol uhoh

Hi Vaughn.

I add an extra 5grams of aakg to my prewos and have hella huge pumps...definitely a difference between when my usin it

Originally Posted by StimBrah

I add an extra 5grams of aakg to my prewos and have hella huge pumps...definitely a difference between when my usin it

This.

Sent from my Evo.

In the methods, if you have them, does it state whether or not it was oral consumption or intravenous administration? All I see is "supplementation" no indication of method of ingestion.

In any event, I have always noticed increased pumps when supplementing with various forms of L-Arg. It's not a bad supplement if you know what it's used for, nothing more.

ITT

bro science > real world science

Originally Posted by MEATHEAD

ITT

bro science > real world science

Get illas dick out of your mouth bro

If you tried UP2.0 preworkout, you'd be a believer too

Originally Posted by MEATHEAD

ITT

bro science > real world science

Absence of evidence is not evidence of absence.

whats going on in hurr?

Brb, texting illa about this thread. I hope ure all prepared to meet ur maker

Originally Posted by J2jud

In the methods, if you have them, does it state whether or not it was oral consumption or intravenous administration? All I see is "supplementation" no indication of method of ingestion.

In any event, I have always noticed increased pumps when supplementing with various forms of L-Arg. It's not a bad supplement if you know what it's used for, nothing more.

I'm about 90% positive its oral. I will have to double check when I'm back at school next week.

Originally Posted by MEATHEAD

ITT

bro science > real world science

ITT meathead smokes too many marshmullumbs

Originally Posted by MEATHEAD

Brb, texting illa about this thread. I hope ure all prepared to meet ur maker

My dad can bench more than your dad.

Originally Posted by Right Hook

Just sayin...


Appl Physiol Nutr Metab. 2012 Jan 17. [Epub ahead of print]
Acute l-arginine supplementation increases muscle blood volume but not strength performance.
Alvares TS, Conte CA, Paschoalin VM, Silva JT, Meirelles CD, Bhambhani YN, Gomes PS.
Source
a Laboratory Crossbridges, Physical Education Postgraduate Program, Gama Filho University, Rio de Janeiro, Brazil.
Abstract
l-Arginine (L-arg) is an amino acid precursor to nitric oxide (NO). Dietary supplements containing L-arg have been marketed with the purpose of increasing vasodilation, thereby elevating blood flow to the exercising muscle and enhancing the metabolic response to exercise. Our goal was to identify the acute effect of L-arg supplementation on biceps strength performance, indicators of NO production (nitrite and nitrate - NOx), and muscle blood volume (Mbv) and oxygenation (Mox) during recovery from 3 sets of resistance exercise. Fifteen males participated in a randomized, double-blind, placebo-controlled study. After withdrawing resting blood samples, the subjects were supplemented with 6 g of L-arg (ARG) or placebo (PLA). Monitoring of Mbv and Mox with near-infrared spectroscopy began 30 min after supplementation and lasted for 60 min. The exercise protocol (3 sets of 10 maximal voluntary contractions of isokinetic concentric elbow extension at 60°·s(-1), 2-min rest between sets) was initiated 80 min after supplementation. Blood samples were drawn at 30, 60, 90, and 120 min after supplementation. Repeated measures ANOVA showed that Mbv significantly (p ≤ 0.05) increased in ARG compared with the PLA during the recovery period of each set of resistance exercise. NOx, Mox, peak torque, total work, and set total work were not significantly different between groups. We found that acute L-arg supplementation increases Mbv during recovery from sets of resistance exercise with no increase in strength performance. It is still premature to recommend nutritional supplements containing L-arg as an ergogenic aid to increase muscle strength during resistance training in healthy subjects.
PMID: 22251130 [PubMed - as supplied by publisher]

insulin increases muscle blood flow and 6g of arginine should cause an insulin spike (followed by a toilet spike). just food for thought

Originally Posted by Patrick Arnold

insulin increases muscle blood flow and 6g of arginine should cause an insulin spike (followed by a toilet spike). just food for thought

Are you sure? I haven't gone over the arginine /insulin response in years but a quick search showed...



Oral arginine does not stimulate an increase in insulin concentration but delays glucose disposal.

Gannon MC, et al. Show all

Am J Clin Nutr. 2002 Nov;76(5):1016-22.

Metabolic Research Laboratory and the Section of Endocrinology, Metabolism, and Nutrition, Minneapolis Veterans Administration Medical Center, Department of Food Science and Nutrition, University of Minnesota, Minneapolis 55417, USA. ganno004@tc.umn.edu

Abstract BACKGROUND: Ingested protein increases circulating insulin concentrations. Several years ago it was also determined that an intravenously administered mixture of 10 essential amino acids stimulated insulin secretion. Of these, arginine was the most potent. The effect was synergistic with administered glucose.

OBJECTIVE: Because the amounts of amino acid administered intravenously were very large and because ingested arginine is partially metabolized in the intestinal mucosa, we were interested in determining whether orally administered arginine stimulates a rise in circulating insulin concentration and whether arginine affects the glucose-induced rise in insulin concentration.

DESIGN: Nine healthy subjects (4 women and 5 men aged 21-52 y) ingested 1 mmol arginine/kg lean body mass, 1 mmol arginine/kg lean body mass + 25 g glucose, 25 g glucose alone, and water only, in random order on separate occasions, at 0800. Blood samples were obtained at baseline and at 10-min intervals over the next 2 h and were assayed for glucose, insulin, glucagon, and amino acid concentrations. The half-time for gastric emptying was determined by scintigraphy.

RESULTS: Unlike with intravenous administration, ingested arginine did not stimulate a rise in insulin concentration. The glucagon concentration was increased. Arginine attenuated and prolonged the glucose rise when it was ingested with glucose. Gastric emptying time was similar after ingestion of glucose alone or arginine plus glucose.

CONCLUSION: Arginine, in an amount likely to be ingested in a high-protein meal, does not stimulate insulin secretion but attenuates the increase in glucose when given with glucose.